Title competitors Liverpool must play a two-legged semi-final against Barcelona during their domestic run-in, while the Citizens no longer have to worry about midweek games.
Some might suggest the lack of fixture congestion would aid City as they bid to see off the Merseysiders in a tight title race but Guardiola feels the opposite is true.
City’s quarter-final exit has meant a change of routine for a side that have played a lot of midweek fixtures due to their progress to the finals of both domestic cups.
City boss Guardiola said: “When that happens in November, December, January, February that helps a lot. That happened for Liverpool. In that period it was better for Liverpool than us.