The highest they can finish is fifth, which means they will be playing in the Europa League next season.
Jose Mourinho was sacked in December and Ole Gunnar Solskjaer was subsequently appointed as manager after his impressive caretaker spell.
He is likely to be given money to spend in the summer and several players will no doubt be heading for the exit.
Speculation has already grown about who might be leaving Old Trafford following Sunday’s final match of the Premier League season.
Juan Mata and Ander Herrera are both out of contract and look set to leave on a free transfer.
Anthony Martial and Paul Pogba are rumoured to be heading for the exit with uncertainty also over the future of goalkeeper David De Gea.